High school student Kazuki Muto thinks he's saving a girl from a monster, but it turns out that she saves him! Kazuki is killed while fighting a homunculus, a malevolent creature that feeds on humans. The girl, Tokiko Tsumura, revives him by replacing his heart with an alchemical device called a kakugane. With this device Kazuki can create his own Buso Renkin, an alchemical weapon in the form of a huge lance, capable of destroying homunculi. With his new weapon in hand, Kazuki decides to join forces with Tokiko to eliminate the homunculi and destroy their master, the strange and eccentric Papillion Masked Creator!
S01:E01 - A New Life
Kazuki Muto's heart is replaced with an alchemical alloy after he is killed by a homunculus.
S01:E02 - The True Form Homunculus
Tokiko and Kazuki investigate the haunted factory and find a homunculus incubator.
S01:E03 - You've Become a Little Stronger
Kazuki begins training with his lance; Tokiko and Kazuki search for the creator of the homunculus.
S01:E04 - Another New Life
Kazuki and Tokiko capture the creator of the homunculi, third-year student Koshaku Chono.
S01:E05 - To Protect Someone
Kazuki and Tokiko fall back from Washio's attack in order to form a plan.
S01:E06 - The Butterfly of Black Death
Koshaku's brother Jiro destroys the flask holding the homunculus.
S01:E07 - Whether or Not You're a Hypocrite
Kazuki is shaken by Chono calling him a hypocrite; Bravo becomes manager of the school dormitory.
S01:E08 - A Night in the Dorm
Bravo begins his training to turn Kazuki into an Alchemist Warrior.
S01:E09 - The Hayasaka Twins
Kazuki befriends Shusui, a follower of the LXE and charged with killing Alchemist Warriors.
S01:E10 - It Seems We're Well Matched
After learning each others identities Kazuki and the Hayasaka twins prepare to fight.
S01:E11 - Til Death Do Us Part
Kazuki pleads for the twins' lives when Tokiko tries to kill them.
S01:E12 - Carnival
Bravo, Kazuki and Tokiko try to take down the LXE before they can revive the Warrior Traitor.
S01:E13 - Signs of Death
Bravo has a hard time defeating Moonface; Kazuki battles the hordes of homunculi.
S01:E14 - Who Are You?
Kazuki and Tokiko battle against Victor; Kazuki's kakugane is destroyed.
S01:E15 - An Intermediate Existence
A berserker-like Kazuki fights Victor; Victor retreats vowing to come back and settle things.
S01:E16 - New Strength
Bravo tells Kazuki about Victor's past.
S01:E17 - When Dawn Comes
Kazuki is revived by the power of the black kakugane; Tokiko vows to stay by Kazuki's side.
S01:E18 - The Escape
Kazuki, Tokiko and Gota head to where the black kakugane was originally located.
S01:E19 - As Long as I Can Protect You
Tokiko and Gota are caught an explosion; Gota protects the injured Tokiko from Negoro.
S01:E20 - With Strength and Feeling
Kazuki and Bravo continue to battle.
S01:E21 - Gone Into Flame
Blaze of Glory engulfs everyone but the Silver Skin-equipped Bravo.
S01:E22 - A Decision Is Required
The Alchemist Army delivers an attack against Victor; Victor's evolution reaches its final stage.
S01:E23 - Boy Meets Battle Girl
Kazuki is faced with the ultimate choice of whether to use the cure on himself or Victor.
S01:E24 - When You Die, I'll Die With You
Kazuki has decided to use the perfected white kakugane on Victor.
S01:E25 - No One Could Ever Take His Place
Following Kazuki and Victor's disappearance into the heavens, peace returns.
S01:E26 - Period
Papillon shows Tokiko the new white kakugane he has forged to return Kazuki back to human form.