Intrepid Dr. Helen Magnus, along with forensic psychiatrist Will Zimmerman, track, study and protect the strange, sometimes terrifying, creatures secretly populating our world.

Helen’s daughter, Ashley is confronted by the mysterious and sinister John Druitt.Will must decide if he’ll join Dr. Magnus in studying the strange fringe world of the Sanctuary.

After Magnus, Ashley and Will free three supernaturally powerful women from a remote Scottish crypt, they’re stalked by a mysterious Cabal determined to reclaim their prisoners.

An investigation into a string of bizarre robberies leads Magnus (AMANDA TAPPING) and Will (ROBIN DUNNE) to a crime ring of thieves who seem to be able to slip between the cracks.

While returning with an Abnormal captured in the Himalayas, Helen and Will’s plane goes down. Waiting for rescuers, other surviving passengers become victims of deadly attacks.

When a mating pair of seemingly harmless Abnormals is brought in for scientific study, the Sanctuary team begins to exhibit some hidden animal attractions for one another.

Helen encounters college friend Nikola Tesla, another exclusive member of The Five, who confides that The Cabal’s come to exact revenge on her for the events in Fata Morgana.

A young artist, who draws detailed pictures from memory, could provide clues to his father’s murder if Will's profiling can determine whether the drawings are real or imagined.

Magnus and Will investigate a distressing call for help deep below the Bermuda Triangle resulting in a deadly battle to save Magnus's life.

Investigating a friend’s disappearance, Will discovers an underground fight club for genetically-altered Abnormals, an operation Magnus thinks is run by her long-deceased father.

Magnus and the Sanctuary team attempt to capture a rare and deadly creature - all under the watchful eye of a local news crew.

Abnormals subjected to an airborne biological agent are compelled to murder. Convinced that The Cabal is involved, Magnus and Druitt assemble The Five to prevent an all-out war.

In the thrilling season finale, Helen leads The Five on a search for a secret labyrinth in the ruins of Bhalasaam, while Ashley and Henry find themselves prisoners of The Cabal.