Investigators and forensics experts review evidence from some of the most notorious murder cases and profile each killer’s behavior and motivations.
S01:E01 - Intern Gone Missing
Government intern Chandra Levy goes missing just hours after she decides to move to a new city.
S01:E02 - Deaths in the Family
Police suspect poison when three members of the same family die of mysterious causes.
S01:E03 - A Killer Cop
An LAPD officer examines the 20-year-old cold case of a married woman who was killed in her home.
S01:E04 - The Casanova Killer
A handsome young man is linked to the murders of four women in different states.
S01:E05 - The Preacher, His Mistress, and Murder
Foul play is suspected after a wife and mother dies in an apparent suicide.
S01:E06 - The Con Artist Killers
A mother and son duo is accused of pulling scams across the U.S. and committing multiple homicides.
S01:E07 - A Woman Scorned
A woman is accused of killing the promising young attorney she had a rocky relationship with.
S01:E08 - A Wolf in Woman's Clothing
The murder of a millionaire doctor's wife sets off a massive manhunt in New England.
S01:E09 - Doctor Death
Police race to catch a genius doctor accused of murder in hospitals across two continents.
S01:E10 - The Acid Lady
After vanishing without a trace, a California father is found to have been murdered.
S01:E11 - If the Walls Could Talk
The disappearance of a surgeon's wife sparks a feverish homicide investigation.
S01:E12 - Bonded in Murder
A street preacher and his teenage partner run a scam to rob and murder unsuspecting men.
S01:E13 - Killer Rabbi
A rabbi's wife is murdered inside the family's home in what looks like a robbery gone wrong.
S01:E14 - A Split Personality
A woman is gunned down in the parking lot of her therapist's office building.
S01:E15 - What Happened to Jana
The search for a local businesswoman who has disappeared turns into a homicide investigation.
S01:E16 - Blood Thicker Than Marriage
Police investigate the apparent carjacking of a husband and wife in East Los Angeles.
S01:E17 - Cheat, Kill, Deny
A California community is rocked when a pregnant wife vanishes without a trace on Christmas Eve.
S01:E18 - They'll Never Find Her Body
A dedicated mother disappears, leaving behind three kids and a husband she planned to divorce.
S01:E19 - A Preference for Poison
When a high school teacher suddenly dies, investigators suspect the man's widow of foul play.
S01:E20 - Blood on the Chef's Apron
The disappearance of a chef's wife leads to the discovery of a ruthless homicide.
S01:E21 - The Acid Trip
A vicious custody battle ends when one of the parents disappears without a trace.
S01:E22 - The Missing Family
A controversial family of atheists mysteriously walks away from its life's work.
S01:E23 - The Escort Murder
A soccer mom moonlighting as an escort disappears from western Colorado.
S01:E24 - Another Vanished
Investigators suspect a serial predator after a mother suddenly disappears in Northeast Texas.
S01:E25 - Snipers in the Capital
A sniper terrorizes Washington, D.C., and the FBI thinks there might be more than one shooter.
S01:E26 - Jodi Arias, the Jilted Murderess
When a young man is murdered in his home, the only suspect with a motive is his ex-girlfriend.
S01:E27 - Phil Spector, Number One With a Bullet
When an aspiring actress is found dead in the home of a music producer, he claims it was suicide.
S01:E28 - Dennis Rader, Btk
A killer terrorizes Wichita, Kan., preying on random people and families.
S01:E29 - Derrick Todd Lee - the Baton Rouge Serial Killer
When women begin getting murdered in Baton Rouge, La., police draw a profile and begin DNA testing.
S01:E30 - The Green River Killer
A notorious killer evades identification for decades despite being arrested twice.
S01:E31 - Stephen Grant
When a mother of two is reported missing, her husband is suspected of foul play.
S01:E32 - Stephen McDaniel
When a law school student is strangled to death, police believe that someone had been watching her.
S01:E33 - The Mutilator of Baton Rouge
A serial killer flies under the radar for years as cops investigate another murderer.
S01:E34 - The Vampire Teens
Some high school outcasts go on the run after their leader commits a savage double homicide.
S01:E35 - The Sadist of San Luis Obispo
A predator who has been released from prison early turns a town into a hunting ground.
S01:E36 - The Bladerunner
An Olympic hero shoots his girlfriend at his home in the middle of the night.
S01:E37 - The Gainesville Ripper
An ex-con on the run for attempted murder sets up camp in Gainesville, Fla.
S01:E38 - Horror in Tennessee
A short order cook falls on hard times, and returns to what he knows best - armed robbery.
S01:E39 - Naposki
The young fiancee of a millionaire has a secret boyfriend and a sinister plan.
S01:E40 - Stanko
Out on parole, an ex-con turned published author goes on a 24-hour killing spree.
S01:E41 - A Family Tragedy
After years of abuse, a high school valedictorian snaps, viciously stabbing his mother.
S01:E42 - Deadly Love Triangle
A bizarre lover's triangle turns lethal, and a mother of two suddenly disappears.
S01:E43 - The Two-Faced Killer
When one bodybuilder wants what another bodybuilder has, the end result is a murder-for-hire.
S01:E44 - The Happy Face Killer
A long-haul trucker with a lust for killing crisscrosses the country looking for his next victim.
S01:E45 - Leonard Lake and Charles Ng
Two ex-Marines abduct women until a petty crime unravels their gig.
S01:E46 - Wendi Davidson
The disappearance of a decorated military man stumps law enforcement and shocks a Texas community.
S01:E47 - Joel Courtney
A drug abuser kills a co-ed in Oregon, then strikes again 1,400 miles away.
S01:E48 - Bobby Joe Long
A serial killer terrorizes the Tampa, Fla., red-light district, targeting women at random.
S01:E49 - Bob Bashara
A well-respected real estate entrepreneur becomes the prime suspect in his wife's murder.
S01:E50 - Gary Heidnick
A former Army medic devises a plan to kidnap women, impregnate them and keep them in his basement.
S01:E51 - The Craigslist Killers
An unemployed teen mom and her new husband concoct a plan to kill a man they meet on online.
S01:E52 - The Killer Conman
A con man lures unsuspecting women with a web of lies and empty promises.