Blythe Baxter embarks on a great new adventure when she moves with her dad into an apartment above a day-camp for pets on the ver. There, she not only discovers new friends in a group of pets, but also an ability to speak and understand them.

Blythe hosts a fashion show for the pets in order to save the pet shop from closing. However, a pair of rich twin sisters, the Biskits, attempt to ruin it after being turned down by Blythe.

Blythe accidentally gives Zoe a bad haircut and scrambles to fix it. Meanwhile, the pets urge Minka to pursue fame with her art.

Zoe's sister Gail must be rescued from the Largest Ever Pet Shop, which is guarded by the Biskit twins and a complex robot.

Pepper is inspired in making a new comedy schtick, which involves stand-up jokes. However, she takes it to far while being oblivious to Penny's sensitive feelings. Blythe is dragged into being friends with the Biskit twins after she stands up for them against a bully during gym.

Blythe is unhappy that her dad has a date for a charity ball. Meanwhile, Penny Ling's displeased with an outfit Blythe is making for her.

Tired of being seen as being too serious, Russell tries to show his fun side, much to the chagrin of a grumpy visiting pet. Sue becomes so inspired by Blythe's style, that she decides to mimic her friend in every way.

Blythe and Zoe try to return a set of keys to a boy who Blythe is believed to have a crush on. The remaining pets meet Esteban Banderas, a parrot who claims to be a legendary hero, but Vinnie is unconvinced. Sunil wonders if he has psychic powers.

Blythe, Zoe, Pepper and Minka get trapped in the apartment's dumbwaiter, and its up to Penny Ling to lead the male pets on a mission to free them.

Mrs. Twombly goes on a desperate search for a rare favorite cleaning product, leaving Blythe to manage the shop. Penny and Vinnie are inspired to create a dancing duo act, while Zoe meets an old modeling rival in the form of Pomeranian Madame Pom.

The pets' imagination goes to their heads when they suspect a Siamese cat is a spy targeting Mrs. Twombly. At school, Blythe takes a big risk in recruiting the Biskit twins to her Mathlete team after seeing their unusual calculation skills.

Vinnie joins Blythe and her dad on a trip to Hollywood to see his favorite dance show. While they are gone, the other pets come up with a solution to keep their TV remote from getting lost.

Famous movie star mongoose Shahrukh is in town shooting his next film and the pets go on set to visit their favorite star. But when Shahrukh follows them back from the movie set, he switches places with Sunil. Now he's in for the ride of his life.

Zoe asks for Penny Ling to share her feelings about a pet shop camper named Digby. Meanwhile, Russell hides inside Blythe's backpack and gets lost at her school.

The pets fill up on one too many treats when they're stuck in the sweet shoppe's pantry with Youngmee's Aunt Christie's pet rabbit, Buttercream.

Blythe rescues the pets when they accidentally send the truck careening down the street, but when she gets blamed, the pets decide to film a reenactment to clear her name.

Blythe's dad wants to spend more time with her, so he decides to stick with Blythe at school. Meanwhile, a shy tortoise named Olive Shellstein visits the Littlest Pet Shop, and Minka is willing to do whatever it takes to have her come out of her shell.

The Biskits order two-hundred cupcakes for their quarter-birthday and a sleepy Blythe is unaware that her new necklace fell into the batter. When she discovers it missing, she and her friends set out to get it back from the party, even though she was uninvited.

Blythe loses her ability to understand the pets while she is sick. Vinnie ends up in the dump and needs help from a fly and rat to take him back home.

Blythe along with her friends enter a cake baking competition, only to to have their recipe stolen by the Biskit twins in an attempt to cheat their way into victory.