In the hands of a brash young pilot and a rebellious head stewardess , Pan Am’s state of the art Majestic Clipper jetliner makes its maiden voyage from New York to London, transporting its passengers and crew into a rapidly changing world of romance and international intrigue.

As Dean hopes a flight to Paris will help him find Bridget, Kate and Laura are stunned to learn their mother is on the plane with them. Meanwhile, Maggie takes aggressive measures to fend off a passenger's unwanted sexual advances.

A flight ferrying journalists to Berlin to cover a important speech by John F. Kennedy provides Maggie a chance to meet the U.S. President. But as Kate tries to help her courier contact escape East Germany, memories of World War II force Colette to confront a childhood trauma.

A last-minute flight to Burma and Indonesia lands Kate in the middle of a frustrating courier mission for the CIA that's further complicated by Laura's naïveté. And as the Majestic Clipper's crew explores Southeast Asia, news of an American space mission leads Ted to recall an ill-fated test pilot mission that upended his career plans.

Laura goes to great lengths to return her engagement ring to her ex-fiancé, while Kate's latest spy mission requires her to score a date with a Yugoslavian racecar enthusiast. Meanwhile, Dean begins a risky affair with the mistress of a Pan Am executive.

As Maggie tries to save her job by adding to the long list of lies she's already told to get hired by Pan Am, Dean's affair with the mistress of the airline's vice president gets serious. Meanwhile, Kate's growing affection for a Yugoslavian diplomat draws her deeper into the world of international espionage.

As Laura and Kate each face relationship challenges, Dean struggles to end his affair with an airline vice president's girlfriend. Meanwhile, Colette volunteers to chaperone a precocious twelve-year-old passenger.

As Kate's personal feelings for Niko Lonza place the life of the Yugoslavian diplomat in danger, Laura's efforts to help an African-American sailor on a layover in New York spark a racist attack.

A violent hurricane and an elderly passenger's heart attack force Dean to make a risky unscheduled landing in war-torn Haiti.

As Maggie risks her job to help fly an activist to a disarmament rally in London, Kate is called upon by the CIA for a mission designed to protect the identities of several western spies. Meanwhile, Ted takes Colette to visit his childhood home.

As Kate looks to cover up her role in the death of a Russian spy in London, Bridget suddenly reappears to resume her career at Pan Am and her relationship with Dean . As Maggie's affair with a pro-war congressman turns serious, Ted looks to Laura for help wooing a childhood friend.

Kate is ordered to track down a missing Russian double agent during a trip to Moscow, while Dean copes with the sudden return of his fiancé Bridget. Meanwhile, Maggie struggles to balance her liberal politics with her feelings for a pro-war politician.

Colette is intrigued by a mysterious passenger on a flight to Rome, while Dean learns that there is a smuggler on board. And as Kate hones her skills as a pickpocket to steal some rocket plans, Ted discovers that his new fiancé is attracted to women.

As a prince’s courtship exposes a surprise in Colette’s past, Ted has second thoughts about marrying Amanda. Kate lands in the middle of the hunt for a double agent, while Maggie is drawn into a pilot’s lucrative smuggling scheme.